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Brown Fat and Thermogenesis Beyond white adipose tissue (the primary fat storage tissue), humans possess brown adipose tissue (BAT) specialized for thermogenesis (heat production)

Melatonin: Acts as a potent antioxidant

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For example, estrogen can restore the expression levels of antioxidant enzymes GPX1 and GPX4, increase the expression of the rate-limiting enzyme -glutamylcysteine synthetase for glutathione synthesis, which maintains the stability of GSH and balances oxidative stress [63, 64]