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Limitations A major limitation to concluding the current body of research on the cancer-related effects of e-cigarette use is the fact that, compared to other health effects, there is a lack of published studies on this topic

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IARC, Lyon, France, pp 393407 Prokopczyk B, Leder G, Trushin N, Cunningham AJ, Akerkar S, Pittman B, Ramadani M, Straeter J, Beger HG, Henne-Bruns D, El Bayoumy K (2005) 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue

The spectrum of severity is variable, ranging from mild symptoms to acute respiratory failure requiring mechanical ventilation