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Discussion In this study, we showed that cigarette smoke exposure, even without the presence of tobacco, promoted lung inflammatory injury, as indicated by the presence of inflammatory cells in BALF and oxidative stress (measured by TBARS levels, a reduced GSH/GSSG ratio, and increased activity of antioxidant enzymes SOD and CAT)
Consequently, a reduction in inflammation should be accompanied by a reduction in cancer risk, which is confirmed by recent observations that reducing inflammation (e.g., through the chronic use of nonsteroidal anti-inflammatory drugs) can reduce the mortality of colorectal cancer and lung cancer [54,55,56]
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