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Additional covariates for exacerbations included FEV 1 % predicted, SGRQ, and gastroesophageal reflux disease (GERD).18 , 19 Exacerbations in the year prior to enrollment (retrospective) and during longitudinal follow-up (prospective) were modeled using negative binomial regression with an offset for exposure time and zero-inflated negative binomial (ZINB) regression to account for the excess number of subjects who reported no acute episodes of respiratory disease (see18 for a description of modeling exacerbations)
It is the most potent of all tobacco species on the planet, and is the primary plant of traditional shamanism in South America
That means your airways cant filter the dust and dirt in the air you breathe
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