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"Electronic cigarettes and vaping: a new challenge in clinical medicine and public health

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Late 20th Century By the late 20th century, the awareness of smoking's health risks increased, and governments had begun heavily restricting cigarette marketing

There is an observable decrease, of around 10%, in the duration of exercise until exhaustion in smokers, which is attributable to a reduction in O2 production in the metabolically active tissues, as a result of arterial O2 desaturation, and to the insufficiency of the O2 transportation, supply and uptake system ( Figure 2 )