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4 Charles Estienne and Jean Liebault, Joyfull Newes out of the newfound world , John Frampton, translator, 1577, f42v

Secondhand smoke exposure is a well-established risk factor for asthma, but it may also have surprising effects in the development of diseases outside of the respiratory system

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As cotinine is completely cleared from the system after 3 days of smoke exposure, we quantified cotinine levels in plasma after 1, 2 and 3 days of treatment in low-dose and high-dose groups to check the exposure level to tobacco smoke (Fig