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Rolfe wanted to introduce sweeter strains from Trinidad, using the hard-to-obtain Spanish seeds he named his Virginia-grown strain of the tobacco "Orinoco", possibly in honor of tobacco popularized by Sir Walter Raleigh's expeditions in the 1580s up the Orinoco River in Guiana in search of the legendary City of Gold, El Dorado

Systemic predisposing factors Aphthous ulcers are associated with conditions such as Behcet disease, cyclic neutropenia, MAGIC syndrome, PFAPA syndrome, and HIV

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While a nicotine-free vape may sound like a better alternative, they are still filled with harmful chemicals, including formaldehyde, heavy metals, and flavoring agents, which could harm your baby