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Further, the PACT Act limits the ability of states and local governments to regulate the delivery carriers involved in remote salescomplicating enforcement effortsand did not place such restrictions on other tobacco products, such as ENDS

In addition, COs induction of HO-1 is likely also disease-relevant, as overexpression of HO-1 is protective in PD models 20,32,55 , polymorphisms in HMOX1 have been associated with PD 56 , and increased HO-1 levels have been reported in saliva samples in early PD 57

Gottlieb left the FDA in April shortly after proposing new restrictions on retail sales of e-cigarettes

and headaches