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doi: 10.1093/annhyg/41.inhaled_particles_VIII.134 Frost G, Darnton A, et al

The preliminary workup consisted of a full blood count and haematinics (to rule out haematinic deficiency-related oral ulceration), connective tissue disease screen, renal and liver profiles, HbA1c and syphilis serology

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What we know is in individuals, young and old, it can rapidly lead to dependence with some pretty substantial changes in brain chemistry as a result. Dopamine is the main agent in cigarette addiction, he says, since it causes a soothing, pleasurable sensation that smokers come to crave