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More specifically, since the absent end-diastolic flows and its associated S/D ratio are viewed as the a bio-marker for adverse birth outcomes (Dicke et al., 2009), simulations with an in silico model may be made for normal and abnormal blood flow patterns, similar to that performed for UAs (Wilke et al., 2018), and for ductus venosus (Leinan et al., 2013) but also incorporating nicotine effect data (Dicke et al., 2009)