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About 440,000 people die each year from smoking-related health problems, and the cost of treatment exceeds $96 billion a year

Nicotine levels increase significantly after smoking each of three high-nicotine cigarettes at 1 h intervals, attributable to the cumulative effect of the three consecutive cigarettes smoked [108]

Results A total of 3 129 259 pregnant individuals were included (mean [SD] maternal age 29.3 [6.0] years), of whom 23 007 (0.7%) had a cannabis-related diagnosis, 56 811 (1.8%) had a nicotine-use diagnosis, and 10 312 (0.3%) had both in pregnancy

By doing so, it counteracts the pleasurable effects of smoking, and helps ease cravings during the transitional period of quitting