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In major distribution centers like the city of Guangzhou, 300 miles west of Yunxiao, laborers still fill and seal the branded packs by hand

At least 45 countries around the world adopted some type of legislation on printing graphic health warnings and signs on cigarette packaging, and the laws of nearly 20 countries specifically provide that health warnings and gruesome graphic pictures of smoking-related disease shall cover no less than 50% of each packet

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this leads to a reduction in the secretion of pro-inflammatory cytokines and an increase in the secretion of anti-inflammatory cytokines