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In addition to carcinogens, they contain substances such as propylene glycol, glycerin, aldehydes and flavorings, all of which are related to lung irritation and respiratory conditions such as chronic obstructive pulmonary disease (COPD), one of the worlds four leading causes of death and disability

In males, an increased incidence of peritoneal mesotheliomas originating from the testicular mesothelium, occurred at 58 and 173 mg/m 3 from the 23rd month onwards, and an increased incidence of subcutaneous fibroma was seen in male rats exposed to 173 mg/m 3 that had survived for 24 months

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