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Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes ( FIGURE 2 In asthma, mitochondrial dysfunction is linked to Th2-driven inflammation characterized by cytokines such as IL-4, IL-5, and IL-13

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