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After infiltration in the arterial wall, monocytes differentiate into macrophages and engulf oxidized low density lipoproteins (LDL) with the help of scavenger receptors creating foam cells, which secrete cytokines that, in turn, recruit more immune cells (145)

Genetic susceptibility, DNA methylation changes, local chronic lung inflammation, and abnormal repair mechanisms in COPD patients are important potential factors for lung cancer development [58,59,60]

Directed By: Alan Taylor Written By: Matthew Weiner Original US Air Date: July 19th, 2007 Points of Interest Characters Salvatore Romano - Sal is asked if he is married, and responds that he isn't, though later in the series he will turn out to be married

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