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Critics claimed that Wilson acted to solicit votes for the next general election (which took place less than a year later), but defenders noted that, since the minimum voting age at that time was 21, this was hardly likely to impact many of the Beatles' fans who at that time were predominantly teenagers

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Moreover, nicotine suppresses M1 microglia cell differentiation and decreases TNF- release from these cells, impairs Th1 and th17 cells differentiation which consequently resulted to the protection of neurons [231]