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Cigarettes speak most clearly in silence and solitude

In fact, it has been estimated that after 2 years of smoking cessation, the activity of the disease and the therapeutic requirement of former smokers are the same as those of patients who have never smoked ( Proposed Mechanisms of Action The pathways by which cigarette smoking exerts opposite effects in CD and UC are hard to establish, due to the large number of components in the smoke and the diverse cellular and tissue functions that may be affected, such as the mucosal barrier, gut microbiota, immune system, microvasculature, and others

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