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Just like this town

Most of Asia, the Middle East, and parts of Africa still treat cannabis as a serious criminal offense

IARC Monogr Eval Carcinog Risks to Humans Volume 100: Islami F, Moreira DM, Boffetta P, Freedland SJ (2014) A systematic review and meta-analysis of tobacco use and prostate cancer mortality and incidence in prospective cohort studies

That would be far more effective than anything we could possibly achieve by finding a more effective drug, realistically. Although not a new drug it has been used in some eastern European countries for decades the first modern trial of cytisine is a bright spot on the horizon