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Human and Animal Rights and Informed Consent All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines)

Nicotine is addictive and not risk-free

The dangers of loss of quality of life are higher than in any other preventable disease

20, 21, 22 Individuals who smoke die on average 10 years prematurely, and those who start smoking younger, are at increased risk of premature death