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Median cotinine concentrations did not significantly differ between the combined-smoking group and the tobacco-only group, again supporting the idea that tobacco exposure was broadly comparable (Pradre et al., 2026)

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The ability of the VLNC intervention to promote smoking cessation was specifically tested at week 12 when participants were offered $100 to abstain from smoking for 24 hours, a modest goal given that most smokers who abstain for 24 hours relapse, and smokers do not get such offers in real life