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Because e-cigarettes are perceived as less harmful and less dangerous than combustible cigarettes, another concern is that teens may be introduced to nicotine use via e-cigarettes, Barrington-Trimis said

It is likely that underlying population heterogeneity and compensatory homeostatic mechanisms within smokers could mitigate the detection of robust abstinence-induced cognitive deficits assumed to arise from neuroplasticity-induced changes following chronic nicotine use [70, 71]