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However, another ascorbic acid supplementation study in smokers reported a significant decrease in urinary levels of 8-epi-prostaglandin (PG) F2 (8-epi-PGF2), a stable product of lipid peroxidation, suggesting a positive modulation of prostaglandin metabolites formed in the arachidonic acid pathway which can functionally compensate for the increased levels of free radical stress due to smoking [77]

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