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A single inhalation from a cigarette results in nicotine hitting the brain within just 10 seconds, and stimulating the same areas of the brain that are also tickled by the consumption of alcohol

In addition to receiving an intranasal dose of nicotine from a commercial source, the women received an injection of a radioactive tracer bound to an enzyme called aromatase, also known as estrogen synthase, which binds to estrogen

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Animal models of abuse and addiction tend to focus on the ability of the drugs to directly control the animals behavior and to induce a rewarding effect that is not dependent on preexisting conditions [161]