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Although the Swiss Tobacco Products Act (TobPA) contains provisions relating to ingredients and emissions, it does not currently provide an approach comparable to the FDAs HPHC list that would allow for the systematic identification and monitoring of harmful or potentially harmful substances in novel nicotine products

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Mechanical factors including respiratory muscle activity [3] associated with pulmonary hyperinflation [4-6], temporal adaptation [7-9] and bronchial hyperresponsiveness [7], psychological factors [10] or emotional and cognitive factors [11] have been proposed to influence the perception of dyspnea