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Pelcovits A, Schiffman F, Niroula R Hematology/oncology clinics of North America 2021

By contrast, scientific studies show that in the aerosol of a heated tobacco product water and glycerine form approximately 90% of the aerosol mass, there are no solid particles and the levels of toxicants are reduced on average by 90% compared to cigarette smoke

Although nicotine is the main chemical that smokers are addicted to, it has relatively minor health effects in the low concentrations used in vaping (except in pregnancy)

Genetics Some genetic disorders, including alpha-1-antitrypsin deficiency, may cause COPD even in non-smokers