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Smokers also see their GP 35% more than non-smokers [Gov.uk] Is the number one preventable cause of death, disability and ill health and is responsible for 80,000 deaths a year in the UK, and 1-in-4 of all cancer related deaths

In order to allow smoke to penetrate the flesh, I would use the Deba knife I bought in Japan last fall to make a series of incisions along both sides of the fish to expose the flesh to the smoke

Sample size guidelines for logistic regression from observational studies with large population: emphasis on the accuracy between statistics and parameters based on real life clinical data