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Of these, 676 were excluded through successive rounds of review, the majority because the studies did not focus on a disease of interest (RSV, bronchiolitis, or LRTI attributable to RSV or bronchiolitis), were not conducted in a population of interest (children younger than 5 years without serious nonrespiratory disease, such as cancer or organ transplant), or did not assess ETS exposure

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Recently, an observational study using Canadian prescription and health outcome databases reported an increase in cardiovascular events among smokers taking varenicline compared to a self-controlled time interval,(144) but limitations of the study design have been noted (145)