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While the above-cited untargeted analytical studies provided a comprehensive overview of the chemical composition of THS 2.2 aerosols and an evaluation of which constituents are present only in THS 2.2 aerosol or are more abundant than in reference cigarette smoke, they do not allow for an unequivocal conclusion on which of the observed differences are an implicit characteristic of the THS platform (i.e., the effect of heating instead of burning tobacco)

Fourth, productivity losses did not include the value of lost work time from smoking-related disability, absenteeism, excess work breaks, and secondhand smoke-related disease morbidity and mortality