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Consistent with the latest research published by Kimura et al., UA promotes the secretion of IL-1 mediated by NLRP3 inflammasomes via regulating the AMP-activated protein kinase (AMPK)-mammalian target of rapamycin (mTOR) mROS and hypoxia-inducible factor-1 (HIF-1) pathway in human peripheral blood mononuclear cells ( Figure 2 ) ( In conclusion, UA has been shown to promote inflammation in a variety of cells

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