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To this end, enzymatic activity from systems such as coagulation has been shown to activate the complement system, which was illustrated to be mainly due to the ability of FXa, FXIa and plasmin to cleave both C5 and C3, and robustly generate C5a and C3a, with the latter being proinflammatory molecules ( Understanding the fundamental operations of the complement system has provided crucial insight into how its delicate equilibrium is maintained, hence ensuring a robust state of homeostasis

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Of those cases, 72% involved children younger than 5

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