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The data from many of these studies has been assessed by independent researchers and while they were largely found to agree that HTPs produce less harmful chemicals than cigarette smoke, independent research did not always agree

Cigarettes contain over 4,000 different chemical compounds, including cancer-causing carcinogens

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These risk patterns were consistent between sexes and across histological types, and were not explained by the type of cigarettes smoked, levels of inhalation or cholesterol and beta-carotene intake