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With that number of littered cigarette butts you can multiply it by an estimate for the volume of a cigarette butt (1.758 cubic centimeters based on King Size and a cylinder with a ~8 mm diameter and ~35 mm height) using its dimensions

The methodology was based on comparing the therapeutic index of the substances, which was defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50)

But thats not to say the standard is insignificant

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