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Smoking and tobacco use Smoking weakens the immune system, reduces blood flow to the gums, and makes it much harder for the body to fight infection and heal damaged tissue

But the short version is that people who feel intensely lonely over long periods switch into an operating mode of hypervigilance

These compounds also elevate intracellular reactive oxygen species (ROS), exacerbating oxidative stress and further promoting adduct formation (Yan et al., 2023

It may be that the nicotine is increasing the death rate from heart disease and that the tar is increasing the death rate from lung cancer and that something else is increasing the death rate for cerebral hemorrhage