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In such studies, the extent of lung inflammation can be assessed by BALF analysis (quantification of inflammatory cells, such as neutrophils and macrophages, and molecular markers, such as cytokines and chemokines), histopathology (assessment of lung infiltration by inflammatory cells, such as neutrophils and pigmented macrophages), and both lung gene and protein expression analysis [41]

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While basic smoking variables such as smoking status (current, former or never) are typically recorded in structured EHR fields, most detailed information such as smoking pack-years, duration, and quit-years are often found in clinical notes only 11,12