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Cases were selected if they had a CRS related diagnosis code ( International Classification of Diseases, Ninth Revision 9 code 473 for chronic sinusitis and 471 for nasal polyps) between January 1, 2000 and May 1, 2004 confirmed by computer tomography or nasal endoscopy

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Methods Aerosol generation A Single Cigarette Smoking Machine (SCSM-STEP, CH Technologies), was calibrated to a puffing regimen of 60 mL puff volume, 4 s puff duration and a 30 s inter-puff interval