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During times of physical or emotional stress, weakened immune system, or extreme fatigue , the immune system can experience a temporary imbalance and trigger an exaggerated inflammatory response in the oral mucosa

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Blood, blood plasma, and blood components collected for the purpose of blood transfusion or the preparation of blood products and sent for testing as part of the collection process, except where the person collecting the blood has reason to believe it contains a Category B infectious substance, in which case the test sample must be shipped as a Category B infectious substance