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m ., in order to minimize childrens exposure to them

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Human beings and laboratory animals metabolise NNK into NNAL and NNKs glucuronides (NNAL-Glucs).17 These compounds are excreted in the urine, and the total amount, known as total NNAL, is a practical and widely used biomarker of NNK exposure.59 The carcinogenic properties of NNAL are quite similar to those of NNK, whereas NNAL-Glucs are detoxi cation products.17 The NNAL biomarker has been extensively used in studies of NNK exposure in smokers, smokeless tobacco users, and non-smokers exposed to involuntary tobacco smoke.59 Advantages of this biomarker include its high reliability and speci city to tobacco products

equal numbers of subjects ( N = 250) in each of four smoking behavior categories (see below)