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COPD with acute exacerbation and acute bronchitis Exacerbation of COPD is a periodic worsening, flare-up or decompensation of symptoms

The involvement of oxidative stress mechanisms in DC activation and cytokine secretion includes a significant increase in protein oxidationmeasured by the formation of carbonyl radicalsand triggers p38 and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling, resulting in the upregulation of CD40

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