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Withdrawal from nicotine increases body weight, neuropeptide Y, and agouti-related protein expression in the hypothalamus, and these proteins have been implicated in regulating appetite and metabolism (Fornari et al., Further Considerations for Nicotine-Mediated Changes in Gene Expression Nicotines actions across the drug use trajectory may be modulated by several factors, in addition to nAChR receptor subtype expression and intracellular signaling cascades

Children are particularly vulnerable to SHS 3,4

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