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Exposure to second-hand smoke has been linked to an increased risk of developing dementia

We carried out the integration analysis using the top 30 dimensions from a canonical correlation analysis (CCA) based on SCTransform normalized expression of the top 3000 most informative genes across donor datasets, where informativeness was defined by gene dispersion (i.e., the log of the ratio of expression variance to its mean) across cells, calculated after accounting for its relationship with mean expression (using the SelectIntegrationFeatures function)

[42] Neuroplasticity within the brain's reward system occurs as a result of long-term nicotine use, leading to nicotine dependence

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