fda tobacco research Centers of Regulatory Science (TCORS) Regulating the Tobacco and Nicotine

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This review summarizes results from studies of humans, preclinical animal models, and cultured endothelial cells that document toxicities of cigarette smoke exposure on pulmonary endothelial cell functions, including barrier dysfunction, endothelial activation and inflammation, apoptosis, and vasoactive mediator production

Cigarettes contain both nicotine and tar as well as chemicals such as ammonia, hydrogen cyanide and carbon monoxide