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Sample Size and Power Calculations As no data are available in the literature on the efficacy of varenicline for gradual cessation in patients with COPD who are poorly motivated to quit, our sample size calculation was based on the cessation rates observed for abrupt cessation in patients with COPD motivated to quit smoking receiving a combination of varenicline and smoking cessation counseling

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Statistical analyses The random-effects inverse-variance weighted method was used as the main analysis due to the most precise estimation it can provide 24

It's the coolest part of the ship to go bar-hopping, as it's also home to the clubby, craft cocktail-serving Elixir Mixology Bar