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Tobacco contains nicotine, cadmium, and lead, which are mutagenic and carcinogenic and cause damage to cells undergoing rapid multiplication, including germ cells in the testis 26

The cost of this proposed rule consists of initial and recurring labeling costs associated with changing cigarette labels to accommodate the new cigarette health warnings, design and operation costs associated with the random and equal display and distribution of required cigarette health warnings for cigarette packages and quarterly rotations of the required warnings for cigarette advertisements, advertising-related costs, and costs associated with government administration and enforcement of the rule