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Robust positive associations between e-cigarette use in baseline never smokers and later ever smoking was observed in studies of young adolescents, older adolescents, and young adults, although these populations are known to differ in risk of smoking onset (Johnston et al., 2017)

Author Contributions Conceived and designed the analysis: Lee JA, Chang Y, Ryu S

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Furthermore, in silico studies showed interaction of 7 nAChRs with RBDs of SARS-CoV-2 spike glycoproteins, indicating dysregulation of the nicotinic cholinergic system and leading to cytokine storm in COVID-19 patients [332, 333]