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This development likely reflects multiple factors, including local and state restrictions on flavored tobacco product sales, FDA regulatory actions, potential COVID-19associated supply chain disruptions, inflation, and a recent proliferation of large format disposable e-cigarettes that may permit higher nicotine consumption per unit

doi: 10.1080/10410236.2017.1407228, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 17.Sinsuwarn N, Rattanakasamsuk K

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Some of these toxic chemicals can directly affect the lungs and contribute to COPD by: narrowing the airways, due to the swelling of tubes in the lungs destroying the alveoli weakening the lungs defenses COPD can lead to chest pain or tightness