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Once in the brain, nicotine binds to receptors that release neurotransmitters, particularly dopaminea chemical that triggers feelings of pleasure and reward

A strength of the study was the comprehensive adjustment of covariates, which included 15 demographic, environmental, and intrapersonal factors, and high participation (80 percent or more) and retention (99 percent) rates

Participants in four groups smoked joints with different ingredients, including placebos: cannabis with psychoactive levels of delta-9-tetrahydrocannabinol (THC) and tobacco with nicotine low THC, nonpsychoactive cannabis and tobacco with nicotine cannabis with psychoactive levels of THC and tobacco without nicotine low THC, nonpsychoactive cannabis and tobacco without nicotine In a memory recall test, the group who smoked active cannabis and tobacco found that tobacco reduced the high effect of cannabis on working memory