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Peptic ulcers can lead to complications such as bleeding in your stomach or duodenum a perforation, or hole, in the wall of your stomach or duodenum, which can lead to peritonitis, an infection of the lining of the abdominal cavity penetration of the ulcer through the stomach or duodenum and into another nearby organ a blockage that can stop food from moving from your stomach into your duodenum Reference This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health