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They concluded that for women who smoke while pregnant "the risk was increased by 26% for having a baby with missing or deformed limbs, 28% for clubfoot, 27% for gastrointestinal defects, 33% for skull defects, 25% for eye defects and 28% for cleft lip/palate." The biggest increase in risk was for their baby having a birth defect called gastroschisis, in which part of its stomach or intestines protrude through the skin

97 The metabolic detoxification that occurs in the liver starts with phase I enzymes that convert a toxic chemical into a less harmful chemical that can be metabolized by phase II enzymes