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Switching from high-nicotine to low-nicotine cigarettes doesnt make smoking safer, as smokers typically compensate by smoking more cigarettes or inhaling more deeply to achieve the same nicotine effect theyre accustomed to

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The frequency of most commonly reported respiratory/oral AEs (such as dry mouth, sore throat, cough) was reduced by the end of the study, lower in the varenicline compared with the placebo group

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