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Smoking is one of the main causes of preventable death global, responsible for conditions which include lung most cancers, heart disorder, stroke, and chronic obstructive pulmonary disease (COPD)

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To compare exposure to these aldehydes from one puff, the authors divided the amount per puff by 500 ml, the average tidal volume of a healthy adult, and found that all flavored products of a single brand exceeded the ACGIH formaldehyde ceiling level by factors of 190270 and the acrolein ceiling level by factors of 1124, depending on the flavor used